Novel autoantibodies and clinical phenotypes in adult and juvenile myositis
نویسندگان
چکیده
Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the clinical associations of the myositis-specific autoantibodies, with particular attention to the recently identified and characterized novel myositis autoantibodies: p155/140, p140 (MJ), CADM-140 (MDA5), SAE, and 200/100.
منابع مشابه
Comparing and contrasting clinical and serological features of juvenile and adult-onset myositis: implications for pathogenesis and outcomes.
PURPOSE OF REVIEW To explore the different characteristics of the serological phenotypes identified in juvenile and adult myositis, consider how differences between the two groups might be explained and discuss how this enhances our understanding of disease pathogenesis. RECENT FINDINGS Current research has focussed on two main areas: first, defining the autoantibody associated disease phenot...
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www.chestpubs.org 2 . Bouros D , Wells AU , Nicholson AG , et al . Histopathologic subsets of fi brosing alveolitis in patients with systemic sclerosis and their relationship to outcome . Am J Respir Crit Care Med . 2002 ; 165 ( 12 ): 1581 1586 . 3 . Betteridge ZE , Gunawardena H , McHugh NJ . Novel autoantibodies and clinical phenotypes in adult and juvenile myositis . Arthritis Res Ther . 201...
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In this review we explore the different characteristics of the serological phenotypes identified in juvenile-onset myositis and consider how the serological sub-classification of patients with juvenile myositis can be advantageous both in terms of reaching what can be a difficult diagnosis and informing on prognosis. Recent studies have described the autoantibody associated disease phenotypes a...
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The juvenile idiopathic inflammatory myopathies (JIIM) are systemic autoimmune diseases characterized by skeletal muscle weakness, characteristic rashes, and other systemic features. Although juvenile dermatomyositis (JDM), the most common form of JIIM, has been well studied, the other major clinical subgroups of JIIM, including juvenile polymyositis (JPM) and juvenile myositis overlapping with...
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OBJECTIVES Juvenile myositis is a rare and heterogeneous disease. Diagnosis is often difficult but early treatment is important in reducing the risk of associated morbidity and poor outcomes. Myositis specific autoantibodies have been described in both juvenile and adult patients with myositis and can be helpful in dividing patients into clinically homogenous groups. We aimed to explore the uti...
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